AB0528 ETHNICITY INFLUENCE ON CLINICAL AND IMMUNOLOGICAL MANIFESTATIONS IN SYSTEMIC SCLEROSIS: ANALYSIS OF 1139 BRAZILIAN PATIENTS.P. D. Sampaio-Barros1, A. B. Bortoluzzo1, B. E. G. Bica1, D. Calderaro1, C. Kayser1, M. W. Keiserman1, C. T. L. Borges1, I. P. Costa1, S. M. Fontenele1, E. A. M. Freire1, R. A. Levy1, S. C. Radominski1, M. C. F. Salgado1, M. B. Santiago1, M. F. L. Sauma1, T. L. Skare1, J. C. M. Szajubok1, R. A. Toledo1, A. F. Zimmermann1, S. C. S. Carneiro1, G. P. Costa1, A. L. P. Duarte1, M. A. R. Loures1, J. J. N. Ribeiro1, S. L. E. Ribeiro1, O. M. Rocha1, N. A. Silva1, V. Valim1, C. C. Vieira1, M. J. P. Vilar1, A. Ranzolin1, F. P. T. Santos1, M. N. L. Azevedo1, J. F. Marques-Neto1, L. E. C. Andrade1
1Systemic Sclerosis Study Group from the Pronuclear Project, Brazilian Society of Rheumatology, Campinas, Brazil
Background: Systemic sclerosis (SSc) may present with distinct clinical and immunological manifestations in patients with white and black ancestry.
Objectives: The authors analysed the influence of ethnicity in a large national SSc cohort in Brazil.
Methods: A common protocol of investigation (including demographic, clinical, and immunological aspects) was applied in 28 university centers from different geographic areas all over Brazil, in the period between 2003 and 2005. The cohort included 664 Caucasian patients (58.3%), with pure white ancestry, 110 patients with pure black ancestry (9.7%) and 356 pardos (31.3%), originated from the white and black miscigenation; 9 patients (0.7%) were Japanese-Brazilian. Clinical variants included 508 cases with limited SSc (44.6%), 504 with diffuse SSc (44.2%), 73 with overlap syndromes (6.4%), and 54 with SSc sine scleroderma (4.8%).
Results: Caucasian ancestry presented statistically significant association with pruritus (p < 0.0001), leucomelanodermia (p < 0.0001), calcinosis (p = 0.009), dysphagia (p = 0.045), higher pulmonary artery systolic pressure at echo-doppler (p = 0.004) and anticentromere antibodies (p < 0.0001). Pure black ancestry presented association with skin ulcers (p = 0.007), tendon friction rubs (p = 0.034), flexion contractures (p = 0.045) and anti-Scl 70 (p < 0.0001). The population of pardos had a higher frequency of abnormal pulmonary function test (p < 0.0001) and smoking habit (p = 0.044).
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Conclusion: Ethnicity was associated with differences in the clinical and immunological presentation in a large national SSc cohort in Brazil.